Your Detox Pathways Might Be Blocked—Here’s How to Know

You’ve tried all the “detox hacks.”

💚 Green juices.

🔥 Infrared saunas.

💊 Expensive supplements.

But you still feel puffy, moody, reactive—and exhausted.

Here’s the truth most practitioners miss:

If your detox genes are compromised, your body doesn’t process toxins efficiently, no matter how clean your diet is.

And when your pathways get congested, your symptoms don’t just “go away”—they build up.

That’s why inside my GeneWise Method, we start with your genetic blueprint. Because if we don’t know what genes are compromised, you’ll always be guessing—and likely making things worse.

Let’s break it down.

⚠️ 5 Signs Your Detox Pathways Are Clogged:

1. You’re sensitive to supplements, smells, or wine 🍷

This often indicates a histamine overload, which is commonly linked to SNPs in DAO or HNMT—genes responsible for breaking down histamine in the body. If these are impaired, even “healthy” foods like fermented veggies or red wine can cause headaches, skin reactions, or anxiety.

2. You get headaches or breakouts after “detoxing” 😵‍💫

This may be a sign your Phase 1 liver detox  is faster than Phase 2 (GST, COMT, etc.), which means toxins get activated—but not cleared. Result? They recirculate, triggering inflammation, acne, migraines, or mood swings.

3. You feel worse after B12 or methylated supplements 💊

If your MTHFR, MTR, or MTRR genes are slow—or your COMT is sluggish—you may not tolerate high doses of methyl donors. Instead of giving you energy, they trigger irritability, insomnia, or anxiety. That’s not a detox crisis—it’s a mismatch between your genes and your protocol.

4. Hormone symptoms are getting worse, not better 🔥

Estrogen detox is governed by genes like CYP1B1, COMT, and GSTP1. If these aren’t working well, estrogen can build up, leading to PMS, heavy periods, fibroids, or weight gain—especially around the hips and thighs.

5. You’re always tired, bloated, or foggy—even on a clean diet 😣

If your mitochondria and detox genes are under-functioning, your body can’t eliminate environmental toxins, heavy metals, or byproducts of cellular metabolism. This leads to a constant low-grade inflammatory state that looks like fatigue, bloating, and brain fog.

❌ Why Juice Cleanses Don’t Work for You

Here’s why trendy detox methods can backfire:

• Green juices? High oxalates and histamines can overload an already slow Phase II liver.

• Liver supplements? If your GST genes are impaired, you might not convert them effectively.

• Saunas? Helpful—but only if your body can sweat out what it’s mobilizing.

Without foundational support for your methylation, sulfur metabolism, and lymphatic flow, you’re not detoxing—you’re recirculating.

✅ What to Do Instead: Gene-Informed Detox

This is where GeneWise changes everything.

We test 170+ genes to build a roadmap that supports:

• Phase 1 liver

• Phase 2 liver (COMT, GST)

• Methylation (MTHFR, MTR, BHMT)

• Histamine clearance (DAO, HNMT)

• Sulfur processing (CBS)

• Mitochondrial function (SOD2)

From there, we map out:

• Low-histamine, gene-supported meals

• Supplement protocols tailored to your SNPs

• Nervous system practices to keep the drainage funnel open

So instead of guessing—or wasting money on supplements that don’t work—you finally support your detox pathways the right way.

Your detox pathways might be blocked—and if you have MTHFR, COMT, or GST variants, your body’s ability to eliminate toxins could be significantly impaired.

🧬 The Functional Truth: Detox Isn’t a One-Size-Fits-All Process

There are 3 main detox phases your body needs to run smoothly:

1. Phase I (Activation) – Your liver breaks down toxins into intermediate forms (often more toxic).

2. Phase II (Conjugation) – These intermediates are neutralized using methylation, sulfation, and glutathione.

3. Phase III (Elimination) – Toxins are moved out via bile, sweat, urine, and stool.

If you’re missing genetic pieces—like reduced MTHFR methylation, sluggish COMT breakdown, or poor glutathione production via GST—you’ll struggle in Phase II. And if you’re constipated or your bile flow is stagnant? Phase III shuts down too.

📉 Signs Your Detox Pathways Might Be Blocked:

• You feel worse on “detox” supplements or protocols

• Hormonal acne, irregular periods, or estrogen dominance

• Chemical sensitivity (perfumes, cleaners, smoke)

• Fatigue, headaches, anxiety, irritability

• You feel better after sweating, sauna, or lymphatic work

🧬 Genes That Impact Detox:

• MTHFR (C677T, A1298C) – Methylation, Phase II

• COMT – Estrogen + neurotransmitter clearance

• GST (Glutathione S-Transferase) – Cellular detox defense

• SULT1A1, UGT1A1 – Sulfation + glucuronidation

• PEMT, ABCG2 – Bile flow + toxin export

If you don’t support these correctly, toxins recirculate—and your body feels it.

🎯 Your Next Step:

✨ Book your free Insight Session

Let’s review your symptoms, your history, and whether a Genetic Blueprint is your next best step.

🧬 Order Your Genetic Blueprint

Includes your full report + a 1-hour 1:1 consult + one free month in GeneWise so you can implement with support.

Don’t waste another month “trying” things that don’t work.

Let’s figure out why your body isn’t detoxing—and what to do about it.

✨ Ready to clear the fog and feel like yourself again?

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SOURCES:

• Paredes S et al. (2018). DAO deficiency and histamine intolerance: diagnostic and therapeutic strategies. PubMed

• Simó C et al. (2018). Role of phase I and II detoxification pathways in detoxification. PubMed

• Glade MJ. (2010). MTHFR polymorphisms and their relationship to folate status and response to folic acid supplementation. PubMed

• James SJ et al. (2006). Metabolic biomarkers of impaired methylation capacity in children with autism spectrum disorders. PubMed

• Zeisel SH. (2006). Choline: critical role during fetal development and possible role in preventing birth defects. PubMed

• Townsend DM et al. (2003). The importance of glutathione in human disease. PubMed