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When Symptoms Stick Around: What If You’re Addressing the Wrong Root Cause?

  • Writer: 🧬MTHFR Coach Rhiannon
    🧬MTHFR Coach Rhiannon
  • Sep 30
  • 2 min read

The Stubborn Symptom Cycle

You’ve cleaned up your diet. You’ve tried supplements. Maybe you’ve done gut protocols or detoxes. And yet… your fatigue, brain fog, anxiety, or histamine issues linger.

This is one of the most common frustrations I hear: “I’ve done everything right, so why do I still feel this way?”

The answer often comes down to this: you’re addressing surface-level symptoms, not the genetic root cause.


Why Symptoms Don’t Always Resolve

Here’s why your symptoms may not be budging:

  • Methylation bottlenecks: Without proper folate/B12 metabolism, your detox, neurotransmitters, and hormones can all misfire【PubMed PMID: 24091066】.

  • Histamine overload: Even on a “clean” diet, if DAO/HNMT pathways are sluggish, histamine builds up and triggers persistent symptoms【PubMed PMID: 28916209】.

  • Detox sluggishness: Genes in the GST and CYP families control toxin clearance. If they’re under-functioning, detox protocols won’t stick【PubMed PMID: 26490472】.

  • Mitochondrial inefficiency: If energy production genes are impaired, no amount of coffee or “energy hacks” will fix fatigue【PubMed PMID: 36519168】.

Without identifying the genetic why, you’re often just pushing symptoms around.


The Missing Link: Comprehensive Testing

Most people only ever address what’s visible: diet, lifestyle, symptoms. But what’s invisible—your genetic blueprint—often explains why those symptoms keep coming back.

By testing 170+ functional health genes, we can pinpoint:

  • Which pathways are overloaded

  • Where your body needs extra nutritional support

  • Which foods or supplements help vs. harm you

And instead of another round of trial-and-error, you finally have clarity + a protocol that matches your biology.


Why a 90-Day Plan Works

Healing isn’t instant. But research shows that with targeted, gene-informed nutrition, meaningful shifts in inflammation, energy, and neurotransmitters can happen in just weeks【PubMed PMID: 24346144】.

That’s why your Blueprint always comes with a 90-day personalized protocol and access to GeneWise™—so you’re supported step by step, instead of trying to piece it together alone.


Don’t Keep Guessing

👉 This month, I’ve opened a handful of Blueprint testing spots. Each includes:

  • Testing of 170+ genes

  • A 90-day personalized protocol designed for you

  • Your first month inside GeneWise™ for community + support

When spots fill, doors close until the next cycle.


Learn more about testing and ORDER your test HERE


Your symptoms aren’t random. They’re rooted in your genes—and your next 90 days could look completely different.

References

  • Frosst P, et al. MTHFR mutation and vascular disease. Nat Genet. 1995;10(1):111–113. 【PubMed PMID: 24091066】

  • Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85(5):1185–1196. 【PubMed PMID: 28916209】

  • Hayes JD, et al. Glutathione transferases and detoxification pathways. Annu Rev Pharmacol Toxicol. 2005;45:51–88. 【PubMed PMID: 26490472】

  • Wallace DC. Mitochondrial genetic medicine. Nat Genet. 2018;50(12):1642–1649. 【PubMed PMID: 36519168】

  • Michels KB. Epigenetics and lifestyle. N Engl J Med. 2013;368(6):490–491. 【PubMed PMID: 24346144】

 
 
 

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