The Real Reason You’re Tired All the Time (Hint: It’s Not Just Stress)

You’ve tried sleeping more. You’ve cut back on coffee. You’ve ruled out thyroid problems.

And yet… you still feel tired all the time.

If this sounds familiar, you’re not alone—and it’s not just in your head.

For many women, chronic fatigue is a symptom, not the root issue. And what your conventional labs aren’t showing is often the key to real answers.

Let’s break it down.

💥 Why Fatigue Isn’t “Just Stress”

Yes, modern life is stressful. But persistent exhaustion—despite a healthy diet and sleep—is usually rooted in deeper dysfunctions. And for my clients, three things come up over and over:

1. Genetic Roadblocks (especially MTHFR)

Your genes dictate how efficiently your body produces energy (ATP), clears toxins, and uses critical nutrients like B12, folate, and magnesium.

The MTHFR gene, in particular, impacts methylation—a process that affects everything from neurotransmitter production to detoxification.

If you’re living with an MTHFR mutation and don’t support it properly?

👉 Your mitochondria struggle.

👉 Toxins build up.

👉 Nutrients aren’t converted into usable fuel.

The result: constant fatigue, brain fog, and even mood swings.

📌 One study found that reduced MTHFR activity impairs folate metabolism and contributes to elevated homocysteine levels—both associated with poor energy and chronic illness. (PubMed)

2. Nutrient Deficiencies You Can’t “Eat Away”

Many clients come to me eating clean, taking supplements… and still feeling awful.

The problem? Their genes can’t absorb or convert key nutrients effectively.

Common deficiencies include:

• B12 (especially if FUT2 is compromised)

• Folate (if MTHFR is impacted)

• Magnesium

• Vitamin D

• Iron

And yes—even if labs say you’re “normal,” your functional levels may not be optimized.

3. Detox Pathways Are Blocked

Your liver needs support to filter out toxins, hormones, and histamine byproducts. But if your genetic blueprint includes slow COMT, sluggish GST, or issues with SOD2… your detox funnel is clogged.

Clients often experience:

• Morning fatigue or “wired but tired” cycles

• Histamine flares (itchiness, allergies, anxiety)

• Hormonal imbalances

• PMS or irregular cycles

• Trouble recovering from workouts or illness

This isn’t a lifestyle issue—it’s biochemistry. And the sooner you stop blaming yourself, the sooner we can build a plan that actually works.

So What Does Work?

It starts with testing, not guessing.

In my Genetic Blueprint consults, we test over 170+ gene variants that impact energy, detox, mood, digestion, and more. From there, we customize your support plan to include:

• Specific supplements tailored to your SNPs

• Low-histamine, energy-boosting nutrition

• Nervous system regulation practices to shift out of fight-or-flight

• Detox + drainage strategies that are safe and MTHFR-friendly

• Lifestyle adjustments that reduce the burden on your genes

Ready for Real Answers?

If you’re tired of feeling tired, let’s dig deeper.

Book a free Insight Session to see if your genes are the missing link.

Or—go straight to the source and order your Genetic Blueprint, which includes 1 month of support inside the GeneWise Membership, where you’ll gain access to protocols that work with your body, not against it.

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Sources:

• MTHFR polymorphisms and their impact on folate and homocysteine metabolism

• Folate, Vitamin B12, and Homocysteine in Health and Disease

• The role of oxidative stress in chronic fatigue

• The detoxification role of glutathione transferases

• Neurotransmitters, methylation and mood disorders