MTHFR and ADD

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a crucial role in the methylation cycle, a process by which the body converts certain nutrients into neurotransmitters. MTHFR deficiency has been linked to a number of health conditions, including ADHD. In this article, we will examine the relationship between MTHFR and ADHD, exploring the evidence and research that supports the connection.

What is MTHFR and its role in the body?

MTHFR is an enzyme that is involved in the conversion of folic acid into its active form, 5-methyltetrahydrofolate. This process is necessary for the production of neurotransmitters such as dopamine, serotonin, and norepinephrine. It also helps to regulate homocysteine levels, which can impact cardiovascular health.

MTHFR variations can result in decreased enzyme activity, which can lead to a buildup of homocysteine and a reduction in neurotransmitter production. There are several different variations of MTHFR, with the most common being C677T and A1298C. The impact of these variations can range from mild to severe, depending on the individual.

Link between MTHFR and ADHD:

There is growing evidence that suggests a connection between MTHFR and ADHD. A study published in the Journal of Attention Disorders found that individuals with ADHD were more likely to have MTHFR variations compared to those without the disorder. Another study published in the Journal of Child Neurology also found a higher frequency of MTHFR variations in children with ADHD.

One theory is that MTHFR variations can impact neurotransmitter production, which can lead to symptoms of ADHD. For example, a decrease in dopamine levels can result in inattentiveness and lack of motivation, which are common symptoms of ADHD. Similarly, low serotonin levels can lead to impulsivity and mood swings, which are also commonly seen in ADHD.

Additionally, MTHFR variations have been linked to oxidative stress and inflammation, both of which have been implicated in the development of ADHD. Oxidative stress and inflammation can damage the brain and impact its function, leading to symptoms of ADHD.

Treatment for MTHFR and ADHD:

There is no cure for MTHFR variations, but there are steps that can be taken to manage the impact on health. One of the most important is to ensure that individuals with MTHFR variations receive adequate levels of folate, which can help to reduce the buildup of homocysteine and support neurotransmitter production. This can be achieved through dietary changes or supplementation.

In addition, holistic treatment for ADHD may include, therapy, dietary and lifestyle changes to manage symptoms. For those with MTHFR variations, it may also be helpful to address any underlying health conditions that may be contributing to symptoms, such as oxidative stress, inflammation, food sensitivities, gut health, and artificial dyes or sweeteners. Working with the MTHFR Coach at Revitalizing Wellness to support these changes and testing will improve your success and decrease your frustration. Learn more about all the offerings from our MTHFR Coach here.

Conclusion:

The connection between MTHFR and ADHD is still being explored, but there is growing evidence to suggest that MTHFR variations may play a role in the development of the disorder. For individuals with MTHFR variations and ADHD, it is important to work with a healthcare provider to determine the best course of treatment and support optimal health. With the right support, it is possible to manage the impact of MTHFR variations and improve overall well-being.

References:

1. Kocovská, E., & Schmitzová, A. (2017). Methylenetetrahydrofolate reductase (MTHFR) gene variants and ADHD. Journal of attention disorders, 21(12), 994-1005.